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Review the Best Kratom Brands, Vendors and Products in 2021

Kratom, a tropical tree native to Southeast Asia, is becoming more popular every day. More options are unfolding about Kratom, giving its users more options than ever. Some Kratom brands have a longstanding reputation for quality, while others are new and unverified.

This brings fierce competition between innovative products and established providers. So, how can users buy Kratom products online? Which Kratom companies are legit? Which Kratom brands are legit according to Reddit and other major digital communities?

This review answers these questions and more. Our editorial team spent countless hours analyzing products, websites, companies, and brands to develop the top Kratom brands available today.

Our Raking of the Best Kratom Vendors and Top Kratom Brand Products

Currently, users can easily buy Kratom online. Whether looking for Premium Kratom, budget Kratom, or even unique Kratom strains and products, they can find companies that offer what they need. However, not every company out there is legit.

This list is a product of close engagement with manufacturers, analysis of lab-testing results, and countless hours of analysis of the best Kratom brands. After a period of serious deliberation, our editorial team came up with the best Kratom brands of 2021:

  • Golden Monk
  • Kats Botanicals
  • Kratom Spot
  • Organic Kratom USA
  • Happy Hippo Herbals
  • Kraken Kratom
  • Mitragaia
  • Super Speciosa
  • Left Coast Kratom
  • Krabot
  • Kratom Life
  • Kratom Krates
  • Craving Kratom
  • Just Kratom
  • Top Extracts
  • Kratom Crazy

Let’s review each of these vendors independently to see which top Kratom products and the most reputable brands users can buy online.

Golden Monk


Golden Monk takes the first position in this list of Kratom’s best-rated and most popular online companies. Available at, this company offers maeng da kratom alongside other popular strains such as a green vein, red vein, and white vein versions, which are some of the most popular strains.

Golden Monk accompanies all its orders with a 100% satisfaction guarantee. Many customers value the company for its pricing, customer service, and general customer experience. Importantly, Golden Monk offers discounted rates for bulk orders starting from $89.99.

Besides, it offers free shipping on orders above $49.99 and $1 in loyalty points for every $10 spent. Golden Monk is one of Kratom’s best online platforms for building long-term business relationships with these incentives.

Kats Botanicals


Kats Botanicals takes the second slot on this list as a Kratom and CBD company that offers a wide range of unique Kratom options not available from other top-ranked Kratom providers on this list. For instance, this company offers dozens of strains and veins of Kratom powder. Besides, it offers popular options like White Horn, Green Indo, Above the Waves, and Chocolate Kratom powder. Kats Botanicals offers affordable capsules, with each bottle priced at $20. From the company, users can find green, red, yellow, white, and blended strains to meet its customers’ needs at affordable rates. Importantly, Kats Botanicals is one of the best-known suppliers in the CBD and Kratom space.

Kratom Spot


Kratom Spot is known for offering high-quality Kratom strains in red, white, and green selections. This company is also one of the few Kratom providers on this list that claim to apply the fair trade Kratom policy. It supports its claims with a 100% satisfaction guarantee. Most importantly, Kratom Spot is also an AKA and GMP-certified vendor, which means its manufacturing location meets certain requirements.

Kratom Spot supplies a full range of Kratom products, including green, red, and white Kratom strains. From the company, users can buy capsules, drinks, leaves, and Kratom extracts, among other options. Additionally, like other vendors on this list, Kratom Spot’s website is loaded with educational information about Kratom. The company also maintains several corporate registration addresses in different locations, including Orange, California, and Portugal.

Organic Kratom USA


Organic Kratom USA is one of the best providers of lab-tested organic Kratom, which is pure, potent, and mature. The company is known for delivering the freshest Kratom products possible, thanks to its same-day shipping, which is unavailable in other companies. From Organic Kratom USA, consumers can find natural Kratom capsules, variety, and sample packs.

A top-rated Kratom platform by Redditors and other Kratom communities online, Organic Kratom USA offers top-rated customer support, among other benefits. Besides, the company claims to send all its team across the globe to find the best Kratom—something that’s rare in other companies.

Popular options from Organic Kratom USA include Green KetaPang Kratom Powder, White Kapuas Kratom Powder, Red Riau Kratom Powder, and Red Horn Kratom Powder, among other strains.

Happy Hippo Herbals


Happy Hippo Herbals is one of the few Kratom companies on this list that support their reputation with high-quality products at affordable rates. While it appears to have a funny-looking website and name, this company offers popular and unique Kratom strains such as Cotton Candy Hippo, Lightning Hippo, Hyper Hippo, and Chill Hippo. This variety makes it easy for consumers to select the exact strain they want according to their targeted benefits.

Speaking of affordability, Kratom on Happy Hippo Herbals starts at $12. Additionally, the company offers liquid Kratom tinctures, Kratom energy shots, and other unique options unavailable from other suppliers. Most importantly, the company accommodates all customers regardless of the size of their orders.

Kraken Kratom


Kraken Kratom is another online platform to consider when it comes to Kratom products. This company is a reliable supplier of Kratom powders, extracts, and capsules, which consumers can purchase online. Its popular products and strains include Ultra Enhanced Indo Kratom Powder, White Vein (Maeng Da Thai Kratom Powder), and OG Red Vein (Maeng Da Thai Kratom Capsules.

Besides, Kraken Kratom offers unique products such as its platinum tea soft gels, Kraken Unleashed Pre-workout Powder, and the Kraken Unleashed post-workout hemp extract. Importantly, the company offers affordable pricing and a range of product options. Overall, Kraken Kratom strives to offer the highest quality Kratom online. Users can purchase the products through the official website at



Mitragaia is a known provider of Kratom powder, capsules, and extracts. All strains from this company undergo testing to confirm their quality, cleanliness, and potency. As stated on the official website at, Kratom from this company is harvested for maturity and potency. Popular products from Mitragaia are Elephant Kratom, Red Malay Kratom Powder, Mitragaia Welcome Sampler, and the Bali Gold Kratom Powder, among others.

The company is ideal for those who are looking for high-quality capsules, powders, and extracts. Besides, it’s one of the few Kratom providers on this list that operates outside the United States. Mitragaia has its main offices in Northern Ireland but also maintains a return address in Henderson, Nevada.

Super Speciosa


Super Speciosa is an online platform that claims to provide pure Kratom and CBD products through its official website. Super Speciosa is an AKA GMP-certified vendor, having successfully met certain location requirements. The company accepts credit cards, such as Visa and MasterCard, something not allowed in other Kratom websites.

According to the official website, Super Speciosa offers a blend of Kratom powders and capsules. However, it doesn’t offer tinctures, drinks, and other Kratom formulas available from other suppliers on this list. Importantly, it offers a range of products in bags of 20g to 5kg, making it easy for consumers to choose what they need easily.

Left Coast Kratom


Left Coast Kratom is a chief provider of Kratom botanicals, teas, and extracts. Some of its outstanding options include OG Bali Kratom Leaf, Left Coast Platinum Tea Tablets, UEI Liquid Kratom Extract, White Vein Borneo Kratom Capsules, and 50X Kratom Extract, alongside other options.

Interestingly, Left Coast Kratom is a family-owned enterprise based in Portland, Oregon. It was founded in 2017 after the pioneers noticed substandard products flooding the Kratom space. Currently, the company is one of the participants in the American Kratom Association’s GMP program. Left Coast Kratom meets certain standards of quality and cleanliness in all its US-based manufacturing facilities.



Krabot is a reliable supplier of ethically sourced Kratom from the forests of Southeast Asia. The company provides some of the unique and beautiful packagings on this list. Popular products from Krabot include the Kratom Super-Spec Capsules, Kratom Extract tablets, Evening Blend Capsules, Krabot Morning Blend, White Maeng da Kratom, and Krabot Evening Blend, among others.

Krabot has its headquarters in Chino Hills, California. The company provides a loyalty program as a token for frequent customers. It’s also one of the few companies on this list that accept cryptocurrency and credit cards.

Kratom Life


Kratom Life has its official website at The company offers same-day shipping for customers who place their orders by 3 PM EST Monday to Friday. From this online platform, users can buy Kratom powder, capsules, extracts, and Kratom kilos. Its packages range from 1kg to 5kg Kratom.

Kratom Life has its headquarters in Wilmington, North Carolina. While it doesn’t stock a wide range of Kratom products like its peers on this list, it emphasizes quality products at affordable prices.

Kratom Krates


Like most Kratom companies on this list, Kratom Krates is an AKA GMP-approved Kratom company. Like some of its peers, the company accepts credit cards. Besides, it offers free shipping and a satisfaction guarantee.

Kratom Krates is a reliable provider of multiple Kratom products, including powders, capsules, extracts, and more. Consumers can purchase products wholesale at discounted rates. Kratom Krates has its headquarters in San Antonio, Florida. Some of its popular options include ultra-enhanced Kratom powders, split and variety packs, and sample packs, alongside other options.

Craving Kratom


Craving Kratom has its official webpage at The company offers fresh and high-quality lab-tested Kratom products to meet the needs of its customers. Craving Kratom accepts multiple payment options, including major credit cards as well as Google Pay and Venmo.

The company also offers same-day shipping. It’s popular for a wide variety of Kratom products, including Kratom extract, Kratom powder, and Kratom capsules. This makes it easy for consumers to customize dosage and size according to their preferences. Importantly, Craving Kratom claims to select some of the most potent strains for its customers with guaranteed highest quality Kratom.


This company is available at as one of the online platforms for top-rated Kratom brands online. It was established with a mission to facilitate innovative research in metabolic, cognitive, and longevity science. To the founders, that was another way of saying the company delivers nutritional formulas, which target various cognitive, energy, and aging goals. Its supplies include a range of Kratom products. is home to more than fifty Kratom products, including strains, colors, powders from various strains, and dosage options. The company offers popular options like Kratom Bali Gold Powder, the Kratom Yellow Borneo powder, and the Kratom Red Thai Powder.

Just Kratom


Just Kratom is a practical Kratom supplier that gives users Kratom powders and pills from various strains and colors. Its powders are available in kilo and half-kilo packages. Popular options from Just Kratom include the Green Malay, Green Maeng Da, Red Bali, and Red Maeng Da Kratom pills and powders. It offers affordable prices ranging between $9.99 and $9.99 for the smallest pills and powders.

Top Extracts


Top Extracts is another online platform for Kratom products. The company’s website is, where consumers can place bulk orders for Kratom products, including liquid capsules, extracts, powders, and sample packs. All products from Top Extract undergo a thorough testing process before they are released to the public for purchase. Top Extracts is a member of the American Kratom Association (AKA).

Top Extracts is home to similar products to other suppliers on this list. However, its selection includes some products that are unavailable from other providers. For instance, the company provides Caffeinated Liquid Kratom Extract and a Flow Liquid Kratom Shot. Importantly, the platform is ideal for those searching for concentrated, convenient, and competitively priced Kratom products online.

Kratom Crazy


Kratom Crazy is available online at This company offers bulk Kratom powders and pills from more than 33 strains. Some popular products include Maeng Da, Super Green Malay, Red Bali, and other Kratom options. It also has educational resources online, which customers can view to help them make the best decisions.

Kratom Crazy stands out for its professional platform, 30-day refund policy, and positive overall shopping experience. Like other reputable Kratom suppliers on this list, Kratom Crazy also claims to get its Kratom directly from the source. This means it sells Kratom products with unaltered strains and maximum potency.

Our Mode of Ranking the Best Kratom Brands

To come up with this list of the best Kratom companies available today, our editorial team considered the following factors:

Overall Quality

Quality played a key role in generating this list. Some companies source their Kratom products from substandard factory farms, while others get their Kratom from superior quality growers. The Kratom products on this list were obtained from top-quality growers.

Kratom Testing

Customers want to buy high-quality Kratom. They want to buy from companies that conduct thorough tests on their products to verify purity and alkaloid content. However, some Kratom companies simply get their Kratom from any grower and sell it directly to consumers. There’s a big difference between the two versions.

Offerings and Variety

This list contains products with a range of dosages, vein color options, and strains. It also contains products from companies that provided capsules, powders, and tinctures, among other options.


Kratom sourcing is still enshrouded with some gray areas. While some companies maintain fair trade sources, others don’t. Some companies also disclose the specific farms or regions from where they obtained their Kratom. This list contains only products with transparent sourcing.

American Kratom Association (AKA) Approval

So far, Kratom is largely unregulated. However, according to the American Kratom Association, specific guidelines are available for companies operating in or selling to the United States. The best Kratom companies comply with the AKA policies.

For instance, AKA compliance requires certain testing and cleaning procedures. Most American Kratom companies order bulk Kratom from overseas suppliers and assemble it in the United States at AKA compliant industries.

cGMP Compliant

Just like the AKA compliance, cGMP compliance can show the difference between good and subpar Kratom companies. Companies with cGMP compliance meet certain manufacturing standards. Some companies bear the AKA GMP compliance, which means they meet American Kratom Association standards. On the other hand, some companies bear the cGMP compliance, which means they comply with the prevailing Good Manufacturing Practices supported by the FDA.

Customer Service and Support

Some Kratom companies display an excellent reputation for customer support and service. Others have poor customer service, support, shady refund policies, and other problems.

Pricing and Value

Some customers can spend hundreds of dollars on Kratom, while others would just do $20 or less for a sample pack. This list contains companies with transparent pricing and good value without being biased towards any particular Kratom pricing range.

Company Reputation and Transparency

Some companies have established outstanding reputations over time for providing high-quality Kratom products. Other companies are new to the industry and just driven by the passion for making quick money.

This list contains products from companies with longstanding reputations for high-quality products and services. The products were sourced from companies with strong quality control practices without using the Kratom brand to gain business mileage.

Advertised Health Benefits

Kratom is not a magic drug that treats all illnesses overnight. The FDA has not even approved Kratom for anything. Some studies also link Kratom to multiple risks. While some companies are open and honest about the substance, others promise a ridiculous amount of benefits with no proof. This list contains products and companies that were open and honest about both sides of Kratom.

What is Kratom?

Kratom is a tropical tree with origins in South Asia and Southeast Asia. Its leaves and other parts have been used in traditional medicine for thousands of years. It is believed to relieve pain and other conditions.

Currently, Kratom is officially in the western world, with many people using it to treat symptoms of depression and anxiety. Others also use Kratom to reenergize the body and mind. Since it’s only a nutritional supplement, Kratom is not licensed or regulated by the FDA.

The FDA is the regulatory authority of foods and drugs, but not supplements. So far, the agency has not approved the use of Kratom for anything, including depression, anxiety, or other purposes.

How Does Kratom Work?

While Kratom is not an opioid, its effects are similar to those of opioids, as compared by many users. It works almost similar to codeine or morphine. Kratom is rich in Mitragynine, an ingredient that binds to opioid receptors in the brain to relieve pain.

Since it attaches to opioid receptors in the brain, Kratom may have some anti-depressant and anti-anxiety properties. Some studies have also revealed that it has sedative effects.

What Does Kratom Do?

When it comes to what Kratom can do, more research is needed to verify any of the advertised benefits of the supplement. Some of the benefits that people claim to derive from Kratom include:

  • Pain and muscle ache relief
  • It eliminates fatigue and boosts energy
  • Supports optimal blood pressure levels
  • Helps with opioid addiction and withdrawal
  • Fights inflammation and boosts immunity
  • Relieves Posttraumatic stress disorder (PTSD), depression, anxiety, and similar conditions

According to some studies, Kratom can suppress appetite to make it easier to lose weight. It can also help alleviate digestive issues. It improves cognitive abilities and improves overall health and wellness.

Traditional Uses of Kratom

Historically, Kratom has been used for centuries throughout the native growing regions. In different parts of Africa and Southeast Asia, Kratom has contributed immensely to the traditional medicine industry.

Traditionally, the product embraces many names like Kakum, ketum, Thom, or biak. In alternative medicine, doctors use Kratom leaves to make herbal teas, which claim to help with fatigue and energy issues, pain, and opioid withdrawal.

How to Use Kratom

Traditionally, Kratom has been used as a type of tea. However, today it’s largely available as capsules. Here are some of the most popular methods of consuming Kratom:

  • Capsules
  • Tinctures
  • Extracts
  • Tablets
  • Gums
  • Teas

When you purchase Kratom online, you literally pay for dried Kratom leaves, ground, and added to a capsule. Once you swallow the capsule, you transfer the active ingredients to your body through the stomach acid, allowing your body to digest them.

Alternatively, some people have smoked Kratom, just like marijuana. However, these methods of consumption are less popular. Kratom’s effects may vary depending on the method of consumption.

Is Kratom Legal?

Kratom remains illegal in several countries, including countries in Southeast Asia where it originates. Kratom is legal at a federal level in the US but remains banned in many states and even cities. Currently, many Kratom websites don’t ship products to selected states or cities.

While countries like Thailand, Malaysia, Australia, Denmark, Romania, New Zealand, and others have banned Kratom, its business still occurs unabated. It remains illegal in several states to buy, use, sell, or possess Kratom in the US. Some of the states that banned Kratom include Indiana, Vermont, Arkansas, Rhode Island, Alabama, and Wisconsin.

On the other hand, some states and cities in the US have passed laws regulating or banning Kratom. For example, Sarasota County in Florida, Denver in Colorado, and San Diego in California have passed laws to ban Kratom in those jurisdictions.

Types and Strains of Kratom

Kratom comes in different strains that can also deliver potentially different effects. While no major research compares different strains of Kratom with one another, there’s plenty of anecdotal evidence online that compares and contrasts various Kratom strains.

Here are the most popular Kratom strains and their effects, based on anecdotal reports online:

Maeng Da

This is a family of Kratom strains, which are known for their longevity and strength. The strains are ideal for those who want to exploit the effects of Kratom and enjoy the effects for a prolonged period. Users can find Maeng Da in different colors, including red, green, and white.

Maeng Da strains are good for stimulation and inducing a feeling of wellbeing. It may also reduce pain. Some users also become more talkative after taking the Maeng Da Kratom strain. The strain is originally from Thailand but currently available in Indonesia and Malaysia.


Indo Kratom strain is originally from Indonesia. According to anecdotal evidence, this strain is less powerful than other Kratom strains. According to users’ reports, it delivers a mild surge in energy while others feel more relaxed. It also fights anxiety and relieves pain while delivering an overall feeling of wellness.

Bali Kratom

This Kratom strain comes from the Indonesian island of Bali. It’s available completely as red vein Kratom, a reddish-colored Kratom is known for its pain relief effects.

Thai Kratom

This Kratom strain originates in Thailand. It’s available in red, green, and white varieties. Thai Kratom effects are based on their color. It can stimulate and create a high, or it can relieve pain.

Borneo Kratom

Borneo is another location-based theme of the Kratom strain that originates from the land of the island of Borneo. It comes in red, green, and white vein options. Many users believe this Kratom strain delivers more sedative effects than other strains on this list. It can also alleviate anxiety and stress, according to some users.

Malaysian Kratom

This Kratom strain comes in green, red, and white options. It claims to provide a balance between stimulating and sedative outcomes.

Green Malay

This Malaysian Kratom is available in a distinctive dark-green color. Taken at low doses, it claims to boost energy and mental focus while alleviating pain. At higher doses, it may deliver sedative effects. Green Malay also delivers other health benefits like pain relief and alleviating anxiety.

Other Kratom Strains

In addition to the mentioned Kratom strains, other Kratom strains are available online. They include Elephant, Bali Gold, Green Ketapang, Green Hulu Kapuas, Red Sandai, etc.

Some Kratom companies rank their strains based on their intended benefits. While some strains are linked to energy and mood, others deliver relaxation and sedation.

Kratom Vein Colors

Kratom veins are available in different colors based on the color they develop during their growth cycle.

For example, a new Kratom plant displays a red color. At the middle of the growth phase, it appears whiter, and towards the end of the growth cycle, it attains a green color. Vein color changes the effects of Kratom. Here are some of the different vein colors and their effects, as stated by users online:

Red (Early Growth Cycle)

Red Kratom strains provide the best relaxation and pain-relieving effects. These strains are ideal for those who are looking to achieve the most noticeable effects of Kratom. For example, when a person struggles with opiate withdrawal symptoms, this strain claims to provide the best results. The effects can last about five hours.

Green (Late Growth Cycle)

Green Kratom strains provide the most powerful pain-relieving effects, as online reports reveal. Additionally, green strains deliver gentle stimulating effects. They can help elevate mood and provide other targeted benefits. Green strains’ effects last about eight hours.

Kratom Benefits—What Does Science Say?

From a scientific perspective, more research is still needed to confirm the safety, efficacy, and benefits of Kratom. Some research supports the use of Kratom, while others suggest it’s not effective or safe.

Similarly, in some studies like the one published in Frontiers of Psychiatry, Kratom delivers both stimulant and sedative dose-dependent effects. It can work as an antinociceptive, anti-depressant, anti-anxiety, and anorectic. At the same time, researchers have questioned the safety of Kratom.

According to a study conducted by researchers on the benefits of Kratom, 85% of the respondents said it decreased pain, while 83% believed it increased energy. Out of the more than eight thousand respondents, 80% said Kratom helped them achieve a less depressive mood.

Kratom Side Effects

Kratom is linked to some side effects, as reported by users surveyed in 2018. A good number of respondents said they experienced negative effects after using Kratom. Some of the common side effects of Kratom include nausea, constipation, and dizziness or drowsiness.

Other users also experienced itching, dry mouth, sweating, tongue numbness, loss of appetite, and increased urination. All these side effects depend largely on the amount consumed, with users taking more than 8g of Kratom getting more side effects.

At the same time, Kratom can deliver more serious side effects like high blood pressure, insomnia, heart palpitations, loss of appetite, cognition issues, loss of libido, and kidney and liver problems. The risk of side effects is greater when users mix Kratom with other substances like alcohol.

In a worst-case scenario, Kratom can be deadly. According to some studies, a Kratom overdose can cause coma or even death. Other studies also reveal that mixing Kratom with alcohol and other substances can lead to life-threatening complications.

Kratom Withdrawal

Users who stop using Kratom can experience withdrawal symptoms, as happens with other psychotic drugs. Some of the withdrawal effects include increased anxiety and depression. Other users also experience insomnia, mood swings, low sexual drive, and nausea.

Typically, users must consume Kratom for an extended period before they can experience withdrawal symptoms. However, the period of consumption also varies widely based on the age of the user, usage, and dosage.

Kratom Dosage

A 2018 review reveals that most people experience the effects after taking an average of about 5g three times a day. A 5g dose, according to the Kratom dosage chart, is considered strong. At that dosage, users can experience sedative, euphoric, and analgesic effects.

The following are the doses and effects associated with Kratom, based on the anecdotal Kratom dose guides online:

  • 1g (entry-level dose): At this dosage, Kratom delivers stimulating and mood-boosting effects. The effects are subtle but still noticeable, especially by new users.
  • 2g (mild dose): At this dosage, Kratom delivers mood-boosting and stimulating effects. Those who miss the effects at the previous lower dosage can feel them at this step.
  • 3g to 4g (moderate dose): At this dosage, Kratom gives users a balanced stimulation, euphoria, sedation, and pain-relieving effects. This dosage is considered moderate.
  • 4g to 5g (strong dose): Most users report a 4-6g dosage to experience the effects of Kratom, as revealed by a 2018 survey. This is a very strong dosage for beginners, which leads to significant sedative, euphoric, and analgesic results.
  • 5g to 8g (very strong dose): This dosage is beyond the power of most people to handle. At this dosage, Kratom delivers significant sedative effects, with some people experiencing euphoria-induced hallucinations.

Generally, Kratom dosage varies widely depending on various factors, including age, weight, tolerance level, and physiology. Users should also note that dosage could change the types of effects they experience while using Kratom. For instance, most people would experience opioid-related effects at higher doses of Kratom (from 5g up).

At lower doses, Kratom delivers more stimulating and energy-boosting results. Those who want to experience the stimulating effects of Kratom should stick to lower doses, while users who want sedative and pain-relieving effects should go for higher doses.

The Best Kratom Brands Final Word

Kratom is available for purchase on many online platforms, giving consumers a wide variety of options. While it’s good for consumers, it also makes it hard for them to choose the right Kratom brand. This list provides top-rated Kratom brands and products at the most affordable prices.

Importantly, the featured companies are known for giving their customers high-quality lab-tested Kratom at discounted rates. Buying the right Kratom product from the right provider could help maximize the effects.

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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